The Panthers play their home games at Ratliff Stadium.
| AUGUST ’22 |
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| 26 | Abilene High | Away | 7:00 |
| SEPTEMBER ’22 |
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| 02 | Waco Midway | Home | 7:30 |
| 09 | Amarillo Tascosa | Away | 7:00 |
| 16 | Harker Heights | Home | 7:00 |
| 23 | Abilene Cooper | Home | 7:00 |
| OCTOBER ’22 |
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| 07 | Odessa High* | Away | 7:00 |
| 14 | Midland Legacy* | Home | 7:00 |
| 21 | Wolfforth Frenship* | Away | 7:00 |
| 28 | San Angelo Central* | Away | 7:00 |
| NOVEMBER ’22 |
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| 04 | Midland High* | Home | 7:00 |
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