The Lady Panthers play their home games at Ratliff Field.
Head Coach: Angela Arebalos
Asst Coaches: Christina Garcia, Til-Lois Fifer, and Vanessa Alonzo
| DATE | OPPONENT | LOCATION | JV | VARSITY |
| FEBRUARY 2021 |
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| 20 | Lubbock/Lub Cooper | Home | 11:00/1:30 | |
| 20 | Lamesa/Greenwood | Away | 1:00/3:00 | |
| 25-27 | Midland Tournament | Away | TBA | TBA |
| MARCH 2021 |
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| 02 | Monahans | Away | 7:00 | 5:00 |
| 05 | Big Spring | Away | 7:00 | 5:00 |
| 06 | Lubbock Coronado | Away | 11:00 | 1:00 |
| 09 | Abilene High* | Away | 5:00 | 7:00 |
| 12 | Wolfforth Frenship* | Home | 4:30 | 6:30 |
| 16 | Odessa High* | Away | 5:00 | 7:00 |
| 19 | Midland High* | Home | 4:30 | 6:30 |
| 23 | San Angelo Central* | Away | 5:00 | 7:00 |
| 30 | Midland Lee* | Home | 4:30 | 6:30 |
| APRIL 2021 |
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| 01 | Abilene High* | Home | 4:30 | 6:30 |
| 09 | Wolfforth Frenship* | Away | 4:30 | 6:30 |
| 10 | Odessa High* | Home | 12:00 | 2:00 |
| 13 | Midland High* | Away | 6:00 | 4:00 |
| 16 | San Angelo Central* | Home | 4:30 | 6:30 |
| 23 | Midland Lee* | Away | 4:30 | 6:30 |
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